GrippeCanadaV3, Main, Exploration, bibRecord, 000148

Hospitalization for Influenza A Versus B.

Identifieur interne : 000148 ( Main/Exploration ); précédent : 000147; suivant : 000149

Hospitalization for Influenza A Versus B.

Auteurs : Dat Tran [Canada] ; Wendy Vaudry [Canada] ; Dorothy Moore [Canada] ; Julie A. Bettinger [Canada] ; Scott A. Halperin [Canada] ; David W. Scheifele [Canada] ; Taj Jadvji [Canada] ; Liza Lee [Canada] ; Teresa Mersereau [Canada]

Source :

Pediatrics [ 1098-4275 ] ; 2016.

RBID : pubmed:27535144

Descripteurs français

KwdFr :
- Adolescent, Canada (épidémiologie), Coût de la maladie, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (), Grippe humaine (diagnostic), Grippe humaine (épidémiologie), Hospitalisation (), Humains, Hôpitaux pédiatriques, Indice de gravité médicale, Modèles logistiques, Mâle, Nourrisson, Nouveau-né, Saisons, Surveillance de la santé publique, Vaccins antigrippaux, Virus de la grippe A, Virus influenza B.
MESH :
- diagnostic : Grippe humaine.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Coût de la maladie, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine, Hospitalisation, Humains, Hôpitaux pédiatriques, Indice de gravité médicale, Modèles logistiques, Mâle, Nourrisson, Nouveau-né, Saisons, Surveillance de la santé publique, Vaccins antigrippaux, Virus de la grippe A, Virus influenza B.

English descriptors

KwdEn :
- Adolescent, Canada (epidemiology), Child, Child, Preschool, Cost of Illness, Female, Hospitalization (statistics & numerical data), Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Influenza A virus, Influenza B virus, Influenza Vaccines, Influenza, Human (diagnosis), Influenza, Human (epidemiology), Influenza, Human (therapy), Logistic Models, Male, Public Health Surveillance, Seasons, Severity of Illness Index.
MESH :
- chemical : Influenza Vaccines.
- diagnosis : Influenza, Human.
- epidemiology : Canada, Influenza, Human.
- statistics & numerical data : Hospitalization.
- therapy : Influenza, Human.
- Adolescent, Child, Child, Preschool, Cost of Illness, Female, Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Influenza A virus, Influenza B virus, Logistic Models, Male, Public Health Surveillance, Seasons, Severity of Illness Index.

Abstract

BACKGROUND

The extent to which influenza A and B infection differs remains uncertain.

METHODS

Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children ≤16 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.

RESULTS

Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P < .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14-1.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P < .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18-5.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34-6.49). Among healthy children with influenza B, age ≥10 years (relative to <6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91-17.57).

CONCLUSIONS

Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.

DOI: 10.1542/peds.2015-4643
PubMed: 27535144

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The extent to which influenza A and B infection differs remains uncertain.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children ≤16 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P < .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14-1.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P < .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18-5.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34-6.49). Among healthy children with influenza B, age ≥10 years (relative to <6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91-17.57).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.</p>
</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>08</Month>
<Day>20</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>138</Volume>
<Issue>3</Issue>
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<Month>09</Month>
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<Title>Pediatrics</Title>
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<ArticleTitle>Hospitalization for Influenza A Versus B.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1542/peds.2015-4643</ELocationID>
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<Abstract><AbstractText Label="BACKGROUND">The extent to which influenza A and B infection differs remains uncertain.</AbstractText>
<AbstractText Label="METHODS">Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children ≤16 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.</AbstractText>
<AbstractText Label="RESULTS">Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P < .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14-1.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P < .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18-5.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34-6.49). Among healthy children with influenza B, age ≥10 years (relative to <6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91-17.57).</AbstractText>
<AbstractText Label="CONCLUSIONS">Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.</AbstractText>
<CopyrightInformation>Copyright © 2016 by the American Academy of Pediatrics.</CopyrightInformation>
</Abstract>
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<ForeName>Dat</ForeName>
<Initials>D</Initials>
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</AffiliationInfo>
</Author>
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<ForeName>Wendy</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Paediatrics, Stollery Children's Hospital, University of Alberta, Edmonton Alberta, Canada;</Affiliation>
</AffiliationInfo>
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<Initials>D</Initials>
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</AffiliationInfo>
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</AffiliationInfo>
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<ForeName>Scott A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scheifele</LastName>
<ForeName>David W</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jadvji</LastName>
<ForeName>Taj</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Section of Infectious Diseases, Department of Paediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Liza</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre for Immunization & Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mersereau</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Centre for Immunization & Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>members of the Canadian Immunization Monitoring Program Active</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>08</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pediatrics</MedlineTA>
<NlmUniqueID>0376422</NlmUniqueID>
<ISSNLinking>0031-4005</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017281" MajorTopicYN="Y">Cost of Illness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006776" MajorTopicYN="N">Hospitals, Pediatric</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="Y">Influenza A virus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009981" MajorTopicYN="Y">Influenza B virus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062486" MajorTopicYN="N">Public Health Surveillance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>06</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>8</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>8</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>6</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27535144</ArticleId>
<ArticleId IdType="pii">peds.2015-4643</ArticleId>
<ArticleId IdType="doi">10.1542/peds.2015-4643</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Alberta</li>
<li>Ontario</li>
<li>Québec</li>
</region>
<settlement><li>Calgary</li>
<li>Montréal</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université de Calgary</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name>
</region>
<name sortKey="Bettinger, Julie A" sort="Bettinger, Julie A" uniqKey="Bettinger J" first="Julie A" last="Bettinger">Julie A. Bettinger</name>
<name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name>
<name sortKey="Jadvji, Taj" sort="Jadvji, Taj" uniqKey="Jadvji T" first="Taj" last="Jadvji">Taj Jadvji</name>
<name sortKey="Lee, Liza" sort="Lee, Liza" uniqKey="Lee L" first="Liza" last="Lee">Liza Lee</name>
<name sortKey="Mersereau, Teresa" sort="Mersereau, Teresa" uniqKey="Mersereau T" first="Teresa" last="Mersereau">Teresa Mersereau</name>
<name sortKey="Moore, Dorothy" sort="Moore, Dorothy" uniqKey="Moore D" first="Dorothy" last="Moore">Dorothy Moore</name>
<name sortKey="Scheifele, David W" sort="Scheifele, David W" uniqKey="Scheifele D" first="David W" last="Scheifele">David W. Scheifele</name>
<name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name>
</country>
</tree>
</affiliations>
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Hospitalization for Influenza A Versus B.

Hospitalization for Influenza A Versus B.

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